Despite current treatment, hypertrophic cardiomyopathy (HCM) can negatively impact patients’ physical, psychological, and social activities1-5

The impact of HCM goes way beyond symptoms. It can adversely affect the following:

Category Patient activity
Physical
  • Walking and exercise1,2,5
  • Sleep1,2,5
  • Activities of daily living (including self-care)1,2
Psychological
  • Mood (general)1,2
  • Anxiety2-4
  • Difficulty adapting or adjusting to exercise recommendations1,2,4
  • Worry, extending to depression, about their condition, particularly among patients with a family history of cardiomyopathy and sudden death4
Social
  • Work: patients reported that their HCM symptoms had an impact on their ability to work2,5
  • Relationships with family2
  • Relationships with friends/others2
  • Limited ability to travel, engage in social activities as well has impacted physical relationships - all leading to an impaired quality of life2
Category PHYSICAL
Patient activity
  • Walking and exercise1,2,5
  • Sleep1,2,5
  • Activities of daily living (including self-care)1,2
Category Psychological
Patient activity
  • Mood (general)1,2
  • Anxiety2-4
  • Difficulty adapting or adjusting to exercise recommendations1,2,4
  • Worry, extending to depression, about their condition, particularly among patients with a family history of cardiomyopathy and sudden death4
Category Social
Patient activity
  • Work: patients reported that their HCM symptoms had an impact on their ability to work2,5
  • Relationships with family2
  • Relationships with friends/others2
  • Limited ability to travel, engage in social activities as well has impacted physical relationships - all leading to an impaired quality of life2

A significant unmet medical need exists to slow or reverse disease progression and address symptoms5

Underdiagnosis & diagnostic challenges

References

Hide references
  1. Naidu, Srihari S, editor. Hypertrophic Cardiomyopathy. Second ed., Springer International Publishing, 2019.
  2. Zaiser E, et al. Patient experiences with hypertrophic cardiomyopathy: a conceptual model of symptoms and impacts on quality of life. J Patient Rep Outcomes. 2020;4(1):102.
  3. Cox S, et al. Health related quality of life and psychological wellbeing in patients with hypertrophic cardiomyopathy. Heart. 1997;78(2):182-7.
  4. Luiten RC, et al. Exercise restrictions trigger psychological difficulty in active and athletic adults with hypertrophic cardiomyopathy. Open Heart. 2016;3(2):e000488.
  5. Ommen SR, et al. 2020 AHA/ACC guideline for the diagnosis and treatment of patients with hypertrophic cardiomyopathy: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2020;142(25):e558-e631.